VEGA: Early local colonic tissue healing with guselkumab maintenance after induction with guselkumab and golimumab combination
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Guselkumab and golimumab are biologic therapies with different mechanisms of action. A substudy of the VEGA trial was designed to explore early molecular changes in a subset of patients. The results help to define the mechanistic contributions of each drug in monotherapy, and as combination.
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Source: Richards D, Vetter M, Germinaro M, et al. DOP54 Tofacitinib for hospitalized acute severe Ulcerative Colitis – the TRIUMPH study. J Crohns Colitis 2024;18(suppl1):jjad212.0094 [DOP54]
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