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Orismilast pharmacology
Key messages
- Orismilast is a highly selective PDE4i, with no or negligible activity against the other 10 PDEs.
- Compared to apremilast, orismilast is a more potent inhibitor of PDE subtypes relevant for inflammation.
- Orismilast also inhibits TNFα secretion more potently than apremilast in PBMC and whole blood.
- Preclinical findings demonstrate orismilast is a potent inhibitor of PDE4 subtypes involved in inflammatory signaling cascades associated with chronic inflammatory diseases.
