
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
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Gout is very common, and although there are urate-lowering therapies available, many people experience flares when they first go on treatment. New strategies explore anti-inflammatory prophylaxis, and dose-escalation protocols.
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Stamp L, Horne A, Mihov B, Drake J, Haslett J, Chapman PT, Frampton C, Dalbeth N. Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial. Ann Rheum Dis. 2023 Dec;82(12):1626-1634. doi: 10.1136/ard-2023-224731. Epub 2023 Aug 31. PMID: 37652661.
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