- Versteijne E, Suker M, Groothuis K, et al. Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: Results of the Dutch randomized phase III PREOPANC trial. J Clin Oncol 2020;38(16):1763-1773.
Perspectives
How does this study impact clinical practice?
- Currently, there is a shifting paradigm worldwide from upfront surgery to neoadjuvant treatment.
- The PREOPANC trial was the first large RCT to show a significant improvement in long-term OS with neoadjuvant chemoradiotherapy compared with upfront surgery in pancreatic cancer.
- Further studies are warranted to understand the optimal neoadjuvant regimen in this patient population to inform clinical practice.
