Determining treatment tolerance and fitness for intensive chemotherapy in older adults with AML: a call to action

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The challenge of determining fitness for intensive chemotherapy in older adults with AML remains an unresolved issue. A comprehensive geriatric assessment has been suggested to address this, capturing variations in multidimensional health that could impact treatment tolerance. Conducting a prospective study to validate these fitness criteria and ascertain if they outperform other benchmarks is critical. Validating these fitness criteria is essential for guiding treatment selection, supportive care interventions, trial eligibility and interpretation of trial results.