Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation
In this medfyle
The pandemic caused by COVID-19 provided a new approach to understanding the role of immunothrombosis. We are witnessing a conceptual change and a new model of coagulation mechanisms, from the enzymatic cascade or the cellular model to knowledge of the physiology of immunohemostasis. This has undoubted consequences for understanding in depth the mechanisms involved in the appearance of thrombosis and for the development of new drugs capable of controlling thromboinflammation, without the side effects of anticoagulant treatment, with the consequent beneficial impact on the management of thrombosis and on personalized medicine.
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