Approaching hypercalcemia in monoclonal gammopathy of undetermined significance: insights from the iStopMM screening study
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The iStopMM screening study explored hypercalcemia in individuals with MGUS to investigate its potential link to myeloma progression. Notably, isolated hypercalcemia never indicated progression to MM. When MM was present, it was accompanied by bone disease and other organ damage. These findings suggest that hypercalcemia in MGUS should be assessed using a standard diagnostic approach, as its causes are usually unrelated to MGUS progression.
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This Medfyle is provided as a service to healthcare professionals. It has been created from content originally published in Blood, American Society of Hematology's official journal.
Original article: Jónsdóttir ÁH, Sigurjónsdóttir HÁ, Thorsteinsdóttir S, Long TE, Sverrisdóttir IS, Eythorsson E, Óskarsson JÞ, Palsson R, Indridason OS, Viðarsson B, Onundarson PT, Ólafsson Í, Þorsteindóttir I, Agnarsson BA, Sigurðardóttir M, Jónsson Á, Hultcrantz M, Durie BGM, Harding S, Landgren O, Love TJ, Kristinsson SY, Rögnvaldsson S. Approaching hypercalcemia in monoclonal gammopathy of undetermined significance: insights from the iStopMM screening study. Blood. 2025 Feb 27;145(9):970-974.
