The Association Between Adverse Childhood Experiences and Primary Headache Disorders: A Prognostic Systematic Review and Meta-analysis
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Key messages
- This systematic review and meta-analysis explored the relationship between adverse childhood experiences (ACEs) and primary headache
- ACEs are strongly associated with primary headache disorders, with evidence of a dose-response relationship, and should be considered an important risk factor for primary headache disorders.
- While ACEs categorized as “threat” versus “deprivation” are both strongly associated with primary headache, these findings provide epidemiological support for such a biological framework as these two dimensions may differentially impact neurodevelopment, with potential for a downstream impact on neurological conditions.
Presenting Author
Claudia Sikorski, PhD (c)
Research Fellow
McMaster University, Ontario, Canada
Claudia Sikorski is currently completing her PhD in Health Research Methodology at McMaster University. Her doctoral research focuses on examining the relationship between coffee and tea and cardiovascular disease and mortality, with consideration of novel biomarkers and genetic variants that might mediate this relationship. She received a CIHR Canada Graduate Master’s Scholarship in 2019. In addition to her doctoral research, she is part of an independent research team investigating the relationships between adverse childhood experiences and negative health outcomes in adulthood, such as headache and chronic pain.
Author disclosures
Claudia Sikorski, PhD (c): I do not have any relevant financial / non-financial relationships with any proprietary interests.
