- Cameron FJ, de Beautfort C, Aanstoot HJ, et al. Lessons from the Hvidoere International Study Group on childhood diabetes: be dogmatic about outcome and flexible in approach. Pediatr Diabetes 2013;14(7):473–80.
- Van Locke M, Battelino T, Tittel SR, et al. Lower HbA1c targets are associated with better metabolic control. Eur J Pediatr 2021;180(5):1513–20.
- Prahalad P, Ding VY, Zaharieva DP, et al. Teamwork, Targets, Technology, and Tight Control in Newly Diagnosed Type 1 Diabetes: the Pilot 4T Study. J Clin Endocrinol Metab 2022;107(4):998–1008.
Findings
What does this study add?
- Mean HbA1c at diagnosis was similar in the 4T and Pilot 4T cohorts (12.3% versus 12.2%), and higher than the historical cohort (10.7%).
- CGM initiation occurred within 30 days of diagnosis in 98.3% of youth.
- At 3, 6, and 9 months post-diagnosis, those in the 4T cohort had LOESS-based mean HbA1c differences of 0.33%, 0.36%, and 0.42% lower than the Pilot 4T cohort and 0.39%, 0.62%, and 0.96% lower than the historical cohort, respectively.
- A greater percentage of youth achieved their HbA1c targets in the 4T study than in the pilot study (67% versus 50%, without significant increase in hypoglycemia.
- CGM use and target setting resulted in increased time in range.
